Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity
نویسندگان
چکیده
منابع مشابه
Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity
Cell-surface CD25 expression is critical for maintaining immune function and homeostasis. As in few reported cases, CD25 deficiency manifests with severe autoimmune enteritis and viral infections. To dissect the underlying immunological mechanisms driving these symptoms, we analyzed the regulatory and effector T cell functions in a CD25 deficient patient harboring a novel IL2RA mutation. Pronou...
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ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2013
ISSN: 1521-6616
DOI: 10.1016/j.clim.2013.01.004